The idea is that Tharizdun is released from his prison and goes to war against all the gods. Eventually, with Good, Evil and Neutrality uniting against Tharizdun, the gods win but Oerth and Greyspace have to be sacrificed. Basically Greyspace is made Tharizdun’s new prison. But the gods no longer have access to the forsaken mortals of Oerth. The rest of the multiverse is saved, however, from the scourge of Tharizdun.
Whatever the question is, the answer is always Greyhawk!
I kid. But, um, That whom we shall not name was trapped in GH (WG4). The forces have trapped him in Greyspace. The mortal of Oerth are forsaken...
Just use the Greyhawk setting and map, and dystopify it.
Add a few custom rules (gods have forsaken, so no cleric casting?) and you should be all set.
IMO.
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